Charla Nash was mauled by a friend's chimpanzee, leaving her without a nose, eyelids, lips or hands. Brigham and Women's Hospital surgeons performed a full facial transplant in a 20-hour procedure.
Initially, she also received two new hands through transplantation as well. A few days later, though, Nash became sick, and the hands were removed.
The first post-surgery pictures of her were released in August 2011.
She said at that time: "I will now be able to do things I once took for granted ... I will have lips and will speak clearly once again. I will be able to kiss and hug loved ones. I am tremendously grateful to the donor and her family."
Richard Lee Norris
Surgery: March 2012
Richard Norris from Virginia was a gun accident in 1997 that took away much of his upper and lower jaws, in addition to lips and nose. He needed a trachea tube to breathe. He wore a surgical mask for 15 years, hiding his deformities from the world.
A team of specialists at the University of Maryland Medical Center performed the procedure, which lasted 36 hours. The surgery involved replacing both jaws, as well as tongue, and skin and underlying nerve and muscle tissue, and an entire set of teeth. Essentially, his entire face was replaced except for his eyes and the back remnant of his throat.
Doctors said Norris' was the most extensive surgery of its kind.
Norris said in a statement in October, "I am doing well. I spend a lot of my time fishing and working on my golf game. I am also enjoying time with my family and friends."
The 37-year-old spoke at a University of Maryland fundraising gala on Saturday, his first public appearance since the surgery, according the a hospital spokesman.
"Thank you for the years spent preparing to give me a new life," he said, according to CNN affiliate WJZ.
In memory of the deceased donor, he said, "Thank you, Joshua. We will always be grateful to you and your family for this gift of life."
Carmen Blandin Tarleton
Surgery: February 2013
Carmen Blandin Tarleton became disfigured after her estranged husband doused her with industrial-strength lye. The lye burned more than 80% of her body, and the burns went all the way through her skin. Children would run away from her because of her appearance.
Tarleton was approved for a full facial transplant in December 2011, and it took 14 months to find a donor. The transplant surgery, performed by specialists at Brigham and Women's Hospital, took 15 hours.
Today, Tarleton is completely blind in one eye and partially blind in the other, but she is still able to live on her own in her apartment in Vermont.
She told CNN she especially looks forward to gaining the strength and coordination to kiss the man she calls "the love of my life."
"I can't pucker and feel yet," she said. "But I am looking forward to that day. I know that day will come."