Two people were rushed to the hospital after a crash on Highway 273.
It was reported at 6:09 p.m. at the intersection of Happy Valley Road, north of Anderson.
According to the CHP, the driver of a red pickup ran a red light and slammed into the driver's side of a silver sedan right in the middle of the intersection.
Rescue crews used the jaws of life to get the victims out of the car.
Police do not believe alcohol or drugs were factors in the crash.
It remains under investigation.