In Missouri, Gov. Jay Nixon declared a state of emergency, as the storm front moved into his state stripping sidings and roofs off homes and causing deadly flooding.
A tornado in St. Charles and St. Louis counties left a path "over 10 miles of significant damage ... that caused dozens and dozens of houses to be literally blown up," the governor told CNN affiliate KSDK on Saturday.
Aerial video from CNN affiliate KMOV showed the second floors of several homes ripped apart, with houses to the front and behind still standing. In one home, a man walked across the exposed second floor, walls and roof gone, at one point picking up what appeared to be a picture as he negotiated debris on all sides. Nearby, shirts still hung on one side of what used to be a closet.
Also damaged was the 10,000-seat Family Arena in St. Charles, county spokesman Colene McEntee told CNN. The damage led three high schools in the Francis Howell school district to cancel graduation ceremonies that had been scheduled for Saturday, KSDK reported.
No one was killed in that tornado, but three people drowned in the state, according to Nixon. Problems with high waters aren't necessarily going away, especially in the southern part of the state.
"Waters are rising, floods are still occurring, and we're asking people to be very safe," the governor said Saturday afternoon.
In Moore, the howls of civil defense sirens sent storm-weary residents scrambling again.
Candace Looper retreated to her windowless laundry room with her cat and stacked couch pillows on top of her.
"I've been praying, and I've been singing 'The Lord's Prayer' and singing 'Amazing Grace,' so I'm OK," she told CNN.
LaDonna Cobb and her husband, Steve, were with their children at their school on May 20 when a tornado demolished the building.
A photograph of Steve Cobb carrying one of their daughters with his wife looking to him with blood on her face emerged as a symbol of Moore's suffering and resilience.
Friday's tornadoes drove them into a shelter and put fear into their hearts again.
"We're terrified," Cobb told CNN's Piers Morgan.
The second tornado was particular unsettling for their children.
"They were not handling it very well. They were pretty upset," Cobb said.
Once it passed, Lewis, the city mayor, rode around town in his pickup.
"This is unbelievable that it could possibly even hit again," he said. "We just started picking up (debris) two days ago."