LOS ANGELES -- Clayton Kershaw tossed a three-hitter, leading the Los Angeles Dodgers to a 4-1 victory over the Washington Nationals before a crowd of 43,352 at Dodger Stadium on Tuesday night.

Dodgers third baseman Juan Uribe hit a two-run home run in the sixth, keeping Los Angeles (78-61) two games ahead of the San Francisco Giants atop the National League West standings. The Nationals (78-59), who own the league's best record, lead the Atlanta Braves by seven games in the NL East.

Kershaw one-hit Washington until center fielder Bryce Harper drove a solo shot into the right-field bleachers with two outs in the seventh inning. Until that point, Kershaw had retired 12 consecutive hitters.

Kershaw (17-3) struck out eight and walked two in eight innings. He fanned 202 batters this season, topping the 200 mark for the fifth season in a row and equaling the mark of former Dodger Don Sutton.

The win also allowed Kershaw, who is unbeaten in his last 19 starts against NL East opponents, to become the first 17-game winner in the major leagues.

Closer Kenley Jansen struck out the side in the ninth for his 39th save.

Washington starter Doug Fister was effective early, but allowed two runs each in the fifth and sixth innings. Fister (12-6) was charged with four runs (three earned) on 10 hits with two strikeouts and two walks in five-plus innings. It was Fister's third straight defeat.

Heralded prospect Joc Pederson received his first big-league start. Pederson, who replaced the struggling Yasiel Puig in center field, blooped a single to center to open the second inning. He went 1-for-3 with a walk.

Starting pitchers Wade Miley of the Diamondbacks and Odrisamer Despaigne of the Padres departed after seven innings with the score tied at 1.

Miley allowed seven hits and two walks with five strikeouts. He also picked two Padres off first. Despaigne allowed four hits and no walks with four strikeouts. He picked one Diamondback off first.

The Diamondbacks used three singles in the top of the fourth to end the scoreless tie.

Back-to-back hits leading off the inning by D-backs second baseman Cliff Pennington and right fielder David Peralta put runner at first and third and no one out. Despaigne struck out first baseman Mark Trumbo, but catcher Miguel Montero flared a single to center to drive in Pennington.

The Padres tied the game in the bottom of the fifth.

Catcher Rene Rivera opened with his second single to end a run of eight straight outs recorded by Miley. Rookie right fielder Rymer Liriano doubled into the right-field corner to move Rivera to third. After center fielder Cameron Maybin struck out, shortstop Alexi Amarista drove Rivera home with a single to right.

NOTES: The Diamondbacks activated OF A.J. Pollock (fractured right hand) and INF Chris Owings (left shoulder strain) from the 15-day disabled list. Further September call-ups could come after Triple-A Reno and Double-A Mobile complete postseason play. ... The Padres added four more players to their roster: RHPs Joe Wieland and R.J. Alvarez, LHP Frank Garces and C Adam Moore. Because Moore and Alvarez had to be added to the 40-man roster and Wieland had to come off the 60-day disabled list, the Padres made three other moves. 3B Chris Nelson and LHP Troy Patton were designated for assignment, and INF Ryan Jackson was promoted from El Paso and transferred to the 60-day DL with a wrist strain. In addition, the Padres brought in RHP Matt Wisler from El Paso for a recon assignment. Wisler, 22, was not activated or added to the 40-man roster.